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. 2013 Jun 6;115(4):556–568. doi: 10.1152/japplphysiol.00363.2013

Table 1.

Monte Carlo simulation study: agreement between the conventional and the optimization methods to fit the prespecified indexes of diastolic function

Conventional Method
Optimization Method
Ric Bias Random error Ric Bias Random error
τ, ms 0.92 2 5 0.99 0 2
V0, ml 0.98 0 4 1.00 0.04 0.5
S, mmHg 0.99 0.06 1.6
Vd, ml 0.84 0.09 3.6
S+, mmHg 0.92 0.21 5 0.99 0.15 1.41
Vm, ml 0.93 0.56 11 0.99 0.26 3.4
dP/dV at V0, mmHg/ml 0.94 10−4 0.1 0.99 10−4 0.02
dP/dV at EDV, mmHg/ml 0.97 0.04 0.1 0.99 10−4 0.05

Ric, intraclass correlation coefficient; τ, time constant of left ventricular (LV) relaxation; V0, equilibrium volume; S, constant of diastolic elastic recoil; Vd, dead volume asymptote; S+, constant of diastolic passive stiffness; Vm, maximum volume asymptote; dP/dV, derivative of LV pressure with respect to volume; EDV: end-diastole volume.