Fig. 3.

Total hyperemic (A) and vasodilator (B) responses (area under the curve) to single-muscle contractions at 10, 20, and 40% MVC during saline (control) and l-NMMA administration in young and older adults. Under control conditions, total hyperemic and vasodilator responses were attenuated in older adults at all contraction intensities. NO synthase inhibition (l-NMMA) blunted the total hyperemic and vasodilator responses at all contraction intensities in young adults. NO synthase inhibition only blunted the total hyperemic response at 10% MVC and the total vasodilator response at 10% and 20% MVC in older adults. *P < 0.05 vs. young. †P < 0.01 vs. control. ‡P < 0.05 vs. control.