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. 2012 Feb 29;32(9):3164–3175. doi: 10.1523/JNEUROSCI.5143-11.2012

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Copyright © 2012 the authors 0270-6474/12/323164-12$15.00/0

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Figure 7. — Changes of neuronal excitability and HCN currents when application of NO/Spermine and l-NNA during the perfusion of Hb in CA1 pyramidal neurons. A, C, Changes of spike firing when application of NO/Spermine (100 μm) and l-NNA (100 μm) during perfusion of Hb (10 μm) at resting potential. B, D, Changes of HCN currents when application of NO/Spermine and l-NNA during perfusion of Hb. E, Summary of the comparison of AP number per minute between control, Hb, Hb + NO/Sp (left) and control, Hb, Hb + l-NNA (right). F, Amplification of changes of HCN currents at −120 mV in B and D. G, Bar graph summarizes the statistical data of comparison of normalized HCN amplitude between Hb, Hb + NO/Sp, and Hb, Hb + l-NNA, respectively. The amplitude of HCN currents at −120 mV in baseline was integrated as 100%. n = 8 cells per group.