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Pooled data showing the effect of isoproterenol (ISO) or endothelin 1 (ET-1) on the force-frequency relationship (FFR) in rat trabeculae with damaged endocardial endothelium. Trabeculae were intact (control) or endocardial endothelium-denuded (EED). The depressed FFR of the EED trabeculae was not improved by ISO (0.1 nmol/l, n = 4, A) or by ET-1 (20 nmol/l, n = 5, B). P < 0.05 vs. treated groups by multivariate ANOVA.
