Fig. 6.

Pooled data showing the effect of ISO plus ET-1 on the FFR in rat trabeculae with damaged endocardial endothelium. FFR was measured in intact trabeculae (control), endocardial endothelium-denuded trabeculae (EED), and EED trabeculae treated with a low concentration of ISO (0.1 nmol/l) and ET-1 (20 nmol/l). The combination of ISO and ET-1 almost completely restored developed force (A) and intracellular Ca²⁺ transients (B) to the levels of control trabeculae. P < 0.05 vs. EED group by multivariate ANOVA; n = 7.