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. 2013 May 31;305(3):L240–L255. doi: 10.1152/ajplung.00355.2012

Fig. 10.

Fig. 10.

Effects of PAR1- and PAR2-selective agonists on thrombin-induced ERM phosphorylation. A: EC were pretreated for 5 min with thrombin (0.5 U/ml), PAR1-selective agonist TFLLR-NH2 (50 μM), PAR2-selective agonist SLIGRL-NH2 (50 μM), or combination of TFLLR-NH2 and SLIGRL-NH2. Pretreatment with vehicle and reversed amino acid sequence peptides RLLFT-NH2 and LRGILS-NH2 used as controls. B: bar graph represents relative densitometry of fold changes in phosphorylated ERM after thrombin, TFLLR-NH2, or SLIGRL-NH2 relative to vehicle-treated control. Results are means ± SE of 3 independent experiments. *P < 0.05, compared with corresponding pretreatment controls.