Table 1.
Top 20 Genes of the Common Angiogenesis Signature
| Rank | Symbol | Full Name | HNSCC Metascore | BC Metascore | CCRCC Metascore | Common Score |
|---|---|---|---|---|---|---|
| 1 | CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.9996 | 0.9967 | 0.9978 | 0.9941 |
| 2 | ELTD1 | EGF, latrophilin and seven transmembrane domain containing 1 | 0.9993 | 0.9967 | 0.9965 | 0.9925 |
| 3 | CLEC14A | C-type lectin domain family 14, member A | 0.9989 | 0.9982 | 0.9924 | 0.9896 |
| 4 | LDB2 | LIM domain binding 2 | 0.9990 | 0.9967 | 0.9938 | 0.9895 |
| 5 | ECSCR | endothelial cell-specific chemotaxis regulator | 0.9995 | 0.9981 | 0.9913 | 0.9890 |
| 6 | MYCT1 | myc target 1 | 0.9969 | 0.9982 | 0.9937 | 0.9889 |
| 7 | RHOJ | ras homolog gene family, member J | 0.9989 | 0.9976 | 0.9910 | 0.9875 |
| 8 | VWF | von Willebrand factor | 0.9986 | 0.9910 | 0.9959 | 0.9855 |
| 9 | TIE1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 0.9989 | 0.9982 | 0.9882 | 0.9853 |
| 10 | KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.9972 | 0.9912 | 0.9967 | 0.9852 |
| 11 | ESAM | endothelial cell adhesion molecule | 0.9958 | 0.9971 | 0.9921 | 0.9850 |
| 12 | CD93 | CD93 molecule | 0.9984 | 0.9932 | 0.9929 | 0.9845 |
| 13 | PTPRB | protein tyrosine phosphatase, receptor type, B | 0.9966 | 0.9930 | 0.9936 | 0.9833 |
| 14 | GPR116 | G protein-coupled receptor 116 | 0.9989 | 0.9950 | 0.9872 | 0.9812 |
| 15 | SPARCL1 | SPARC-like 1 (hevin) | 0.9974 | 0.9956 | 0.9878 | 0.9809 |
| 16 | EMCN | endomucin | 0.9985 | 0.9967 | 0.9823 | 0.9776 |
| 17 | ROBO4 | roundabout homolog 4, magic roundabout (Drosophila) | 0.9895 | 0.9967 | 0.9876 | 0.9740 |
| 18 | ENG | endoglin | 0.9981 | 0.9910 | 0.9839 | 0.9732 |
| 19 | TEK | TEK tyrosine kinase, endothelial | 0.9992 | 0.9984 | 0.9754 | 0.9730 |
| 20 | S1PR1 | sphingosine-1-phosphate receptor 1 | 0.9862 | 0.9979 | 0.9885 | 0.9729 |