(A) Time course of the average body weight from all four groups, as indicated, represented as the percent of baseline. (B) Lean mass/fat mass ratio of animals, as indicated, after 13 weeks of treatment with FST288. (C & E) Time courses of lean mass and fat mass measurement, respectively, during the period of FST288 administration, plotted as the percent of body weight. (D & F) Lean mass/body mass and fat mass/body mass, respectively, of animals, as indicated, after 13 weeks of administration of FST288, plotted as the change (difference) from the baseline values. *, ** and *** indicate p < 0.05, <0.01 and <0.001, respectively. p-value measurements in A, C and E are between FST 0 and FST 100.