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Criteria for individual diagnostic parameters used to categorize the parameters into different evidence levels

Diagnostic parameter	Diagnostic criteria	Evidence level
OptiVol	Fluid index ≥100	4
	60≤ Fluid index <100	3
	30≤ Fluid index <60	2
	0≤ Fluid index <30	1
	Data not available	−1
Night heart rate (NHR)	AvgNHR ≥85 b.p.m. OR AvgNHR ≤55 b.p.m.	2
	NHRtrendIndex*≥NHR trend threshold	2
	If condition for evidence level 2 not met	1
	Data not available	−1
Patient activity (ACT)	AvgACT ≤60 min	2
	ACTtrendIndex*≥ACT trend threshold	2
	If condition for evidence level 2 not met	1
	Data not available	−1
Heart rate variability (HRV)	AvgHRV ≤60 ms	2
	HRV trend index*≥HRV trend threshold	2
	If condition for evidence level 2 not met	1
	Data not available	−1
Arrhythmia/pacing combination	VTepisodes ≥5 OR Shock = ‘True’ OR AF burden ≥1 h/day OR MeanVRAF ≥90 b.p.m. AND AF ≥6 h/day OR %Ventricular pacing ≤90% AND CRT device	1
	Two or more of the above 5 arrhythmia conditions met	2
	No condition met OR data not available	−1

*Trend index is computed as a running cumulative sum of the difference between short- and long-term averages over a 14-day period. Trend Index is compared with thresholds which are related to the value of the long-term average.