Table 1.

Major and minor HIVDR mutations found in the RT gene in specimens collected from HIV-1 seropositive ART-naïve pregnant women in the Eastern Region of Ghana (2007–2009)

Sample ID	Major DR Mutation	Minor DR mutation
AGDR4	NONE	E138Q
AGDR12	NONE	K101Q
AGDR35	NONE	K103R
AGDR37	M184V, Y181C	NONE
AGDR41	NONE	A98G

A98G is a minor mutation that reduces Nevirapine susceptibility by 2 to 3-fold. It is selected by Nucleoside Reverse Transcriptase Inhibitors (NRTIs) and Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs). K101Q is weakly associated with NNRTI therapy and minimally reduces susceptibility to each of the NNRTIs.

K103R occurs in about 1%–2% of untreated persons and by itself has no effect on NNRTI susceptibility.

E138Q is weakly associated with NNRTI therapy. It may contribute to decreased NNRTI susceptibility in certain genetic contexts.