. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Medchemcomm. 2013 May 17;4(7):1073–1078. doi: 10.1039/C3MD00130J

Table 2.

Comparative GI₅₀ (nM) values of compound 6, docetaxel and vinblastine in P-gp expressing cell lines

	Cell lines	6	Doc	Vin
Prostate	PC3	8.6	2.5	5.2
Prostate	^aPC3-DR	7.6	54 (22)	n.a.

Ovarian	OVCAR8	5.2	0.5	2.8
Ovarian	NCI-ADR/Res	3.2	196 (392)	1402 (500)

Kidney epithelium	LLC-PK1	9.7	0.17	1.5
Kidney epithelium	L-MDR1	11.7 (1.2)	106.6 (627)	86.8 (58)

na: Not analyzed,

PC3-DR: PC3 cells maintained in 3.6nM docetaxel. Numbers in parenthesis represent the relative resistance factor between P-gp expressing and non-expressing cells.