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. 2013 Aug 14;4:201. doi: 10.3389/fphys.2013.00201

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Copyright © 2013 Herrmann, Ninkovic, Kohl and Pardo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PIST influences K_V10.1 function. (A) Current-voltage relationship of K_V10.1 expressed in Xenopus oocytes with or without PIST. Current amplitudes were significantly larger in oocytes coinjected with PIST (N = 4; ^**p < 0.01; ^***p < 0.001). (B) After normalization to the current value at +100 mV, the current-voltage plots overlap, indicating that the voltage-dependence of the channel is not altered by PIST. (C) Relative current amplitude (at + 80 mV) in oocytes co-expressing PIST isoforms with respect to K_V10.1 alone (N = 19). PIST (N = 18) induced a significant increase (p < 0.05), while nPIST (N = 10) and nsPIST (n = 14) did not alter current amplitude. (D) Co-injection of sPIST reduced the current amplitude both in the absence (N = 8) and in the presence (N = 8) of PIST. (E) PIST expression did not affect K_V10.2 current amplitude.