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Homeostasis model assessment of insulin resistance (HOMA-IR) of each group after the treatment period in LETO (A) and OLETF (B) rats. HOMA-IR was calculated from the following formula: HOMA-IR=[fasting serum insulin (µU/mL)]×[fasting serum glucose (mmol/L)]/22.5. Fasting serum adiponectin levels of each group after the treatment period in LETO (C) and OLETF (D) rats. LETO, Long-Evans Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima Fatty. *p<0.05; †p<0.01; ‡p<0.001.
