Table 4.
Hazard ratio of hypertension according to rate of body mass index change (slope) quartiles over 46 years in 1132 men in The Johns Hopkins Precursors Study. Slopes were derived from random effects models using BMI values up to the age of diagnosis of hypertension. 95% confidence interval in parentheses.
| Rate of BMI change (slope in kg/m2 per year) |
Unadjusted hazard ratio |
Hazard ratio adjusted for BMI only |
Hazard ratio adjusted for baseline characteristics¶ |
Hazard ratio adjusted for time-dependent characteristics‡ |
|---|---|---|---|---|
| First Quartile (−11.1 to -−1.79) |
1.00 | 1.00 | 1.00 | 1.00 |
| Second Quartile (−1.80 to -−0.11) |
1.35 (1.03-1.77) | 1.43 (1.09-1.87) | 1.59 (1.18-2.16) | 1.51 (1.08-2.12) |
| Third Quartile (−0.10 to 1.59) |
1.84 (1.42-2.39) | 1.94 (1.49-2.52) | 2.13 (1.58-2.86) | 2.13 (1.53-2.97) |
| Fourth Quartile (1.60 to 15.9) |
2.37 (1.84-3.06) | 2.58 (1.99-3.33) | 2.48 (1.85-3.32) | 2.52 (1.82-3.49) |
¶
Models adjusted for parental premature hypertension and baseline number of cigarettes smoked, cups of coffee taken, alcohol intake, physical activity and BMI measured at baseline.
‡
Models adjusted for parental premature hypertension and time-dependent number of cigarettes smoked, cups of coffee taken, alcohol intake, physical activity and BMI measured at baseline.