Table 4.

Correlations Between Brain Perfusion During Smoking Cue Exposure and Smoking Cue–Elicited Craving^a

Region	Both Groups at Time 1				Varenicline Group at Time 2				Placebo Group at Time 2
	x	y	z	t	x	y	z	t	x	y	z	t
Medial OFCb	2	32	−12	2.67					8	60	−22	3.77
									−6	62	−18	3.37
									16	54	−20	4.00
VSb	26	16	−2	2.93
VS and medial OFCb	24	14	−14	2.42
Lateral OFC									30	36	−20	−3.27
									−48	16	46	−6.12
									44	48	−8	−3.84
Dorsolateral prefrontal cortex									−30	34	12	−6.84
Ventromedial prefrontal cortex	12	54	−6	3.00
Parahippocampus					18	−22	−8	3.94
Anterior dorsal insula					−38	−26	26	6.42
					−48	18	50	3.66
Posterior dorsal insula	40	−10	2	2.94					40	−6	2	3.02
Posterior cingulate	12	−40	40	4.71					8	−44	46	3.05
Precentral gyrus					46	−12	36	5.76
					62	2	24	4.88
Superior parietal (precuneus)					2	−60	58	3.84
Superior temporal gyrus					60	16	−18	3.80
Anterior occipital sulcus					−38	−70	−4	3.53
Supramarginal gyrus									−54	−46	34	−3.89
Middle frontal gyrus
Inferior temporal cortex	54	−24	−22	−3.44
Cerebellum	−30	−48	−26	3.27

Abbreviations: OFC, orbitofrontal cortex; VS, ventral striatum.

^aListed are the coordinates x, y, z from the suprathreshold voxel within a cluster and t values from the regions that correlated with smoking cue–elicited craving as assessed by the “craving” item of the Shiffman-Jarvik withdrawal scale in all groups at both time points. Activations are significant at P < .001 (uncorrected at the cluster level). Left-sided brain responses are indicated by negative x-coordinate values. Negative t values are regions wherein activation was reduced. (Note that lateral OFC activity decreased in the placebo group at time 2.)

^bRegions that were a priori and that approached significance.