Table 1:

Comparison of in silico metabolic reconstructions of P. falciparum

Authors (year of publication)	Information about the modela
	Metabolites	Reactions	Genes	Compartmentsb
Yeh et al. (2004) [14]	525	696	—	—
Fatumo et al. (2009) [11]	554	575	—	—
Huthmacher et al. (2010) [12]	P: 1622 E: 566	P: 1375 E: 437	P: 579	P: c, m, a, n, r, v, g; E: e, c
Plata et al. (2010) [13]	915	1001	366	P: e, c, m, a
Bazzani et al. (2012) [10]	P: 1622 H: 1149	P: 1394 H: 2539	P: 579 H: 704	P: c, m, a, n, r, v, g; H: c, r, g, l, m, n, p, b, s

The first two models [11, 14] were built using graph-based approach and the following are constraint-based models [10, 12, 13].

^a‘P’ denotes the model of the parasite, ‘E’ human erythrocyte, ‘H’ human hepatocyte.

^bAbbreviated names of compartments: e, extracellular space; c, cytosol; m, mitochondrion, a, apicoplast; n, nucleus; v, digestive vacuole; r, endoplasmic reticulum; g, Golgi complex; l, lysosome; p, peroxisome; b, bile canaliculus; s, sinusoidal space.