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. 2013 Jul 31;143(9):1509–1519. doi: 10.3945/jn.113.174599

TABLE 1.

Parameter values used in the model1

Parameter Units Model value Literature values References
l-transporter (Vtrpgs, Vtrpsm, Vtrpsl)
 Km μmol/L 64 64 (41)
 Vmax μmol/(L · h) 400, 840, 2000 —2
VTDO
 Km μmol/L 43 24.6–250 (50, 82, 83)
 Vmax μmol/(L · h) 100.5 —
VAFD
 Km μmol/L 50 50–180 (53, 54)
 Vmax μmol/(L · h) 2000 —
VKMO
 Km μmol/L 25 25 (84)
 Vmax μmol/(L · h) 78.4 —
VKYN1
 Inline graphic μmol/L 240 240–1000 (56, 85)
 Inline graphic μmol/L 0.88 0.88 (24)
 Inline graphic μmol/L 20 20 (57)
 Vmax μmol/(L · h) 128.46 —
VKYN2
 Inline graphic μmol/L 3 3–45 (57) (56, 85, 86)
 Inline graphic μmol/L 0.88 0.88 (24)
 Inline graphic μmol/L 20 20 (57)
 Vmax μmol/(L · h) 512 —
VKAT1
 Inline graphic μmol/L 4700 2000–5000 (87–90)
 Inline graphic μmol/L 0.85 0.85–7 (24, 88)
 Vmax μmol/(L · h) 1998 —
VKAT2
 Inline graphic μmol/L 5000 2000–5000 (87–90)
 Inline graphic μmol/L 0.85 0.85–7 (24, 88)
 Vmax μmol/(L · h) 47,952 —
VHAO
 Inline graphic μmol/L 10 2–21 (91, 92)
 Vmax μmol/(L · h) 2000 —
Removal coefficients3
 d3 h−1 0.2
 d4 h−1 3
 d5 h−1 240
 d6 h−1 8
 d7 h−1 6
 d8 h−1 40
 d9 h−1 0.2
Other coefficients3
 k2 h−1 0.0002
 k13 h−1 1
 k14 h−1 1.2
 m h−1 7
1

Vmax values used in constructing the model and conducting simulations are shown (see text for explanations). AFD, aryl formamidase; HAO, 3-hydroxynalic acid oxygenase; hk, 3-hydroxykynurenine; KAT, kynurenine aminotransferase; KMO, kynurenine 3-monooxygenase; kyn, kynurenine; KYN, kynureninase; PLP, pyridoxal 5′-phosphate; TDO, tryptophan 2,3- dioxygenase; trpgs, tryptophan from gut to portal circulation; trpsl, tryptophan from portal circulation to liver; trpsm, tryptophan from peripheral circulation to muscle.

2

Dashes indicate that values for Vmax were not taken from the literature.

3

See text for Literature values.