TABLE 3.
Model prediction of the effect of extent of induction of TDO activity on urinary excretion of tryptophan metabolites1
| TDO percentage of basal activity |
|||||
| Trp metabolites in urine | 100 (baseline) | 120 | 150 | 180 | 200 |
| μmol/L | |||||
| Kyn | 2.00 | 2.12 | 2.25 | 2.35 | 2.41 |
| HK | 1.43 | 1.52 | 1.62 | 1.70 | 1.74 |
| XA | 1.40 | 1.48 | 1.58 | 1.65 | 1.69 |
| KA | 3.44 | 3.64 | 3.87 | 4.05 | 4.15 |
| HaA | 3.21 | 3.33 | 3.47 | 3.57 | 3.62 |
| AA | 3.37 | 3.49 | 3.63 | 3.73 | 3.79 |
| QA | 15.9 | 16.4 | 17.1 | 17.5 | 17.7 |
1
AA, anthranilic acid; HaA, 3-hydroxyanthranilic acid; HK, 3-hydroxykynurenine; KA, kynurenic acid; Kyn, kynurenine; QA, quinolinic acid; TDO, tryptophan 2,3-dioxygenase; Trp, tryptophan; XA, xanthurenic acid.