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. 2013 Jul 25;8(7):e69228. doi: 10.1371/journal.pone.0069228

Figure 3. Flexible C-terminus of DR1 molecule binds in partially empty peptide-binding groove of adjacent DR1 molecule.

Figure 3

(A) Two molecules in the crystal lattice are shown depicting a contact formed by DRα (orange) C-terminus of one DR1 molecule binding to the partially empty peptide-binding groove of the other DR1 molecule (cyan/blue). (B) Close-up view of the interactions between the neighboring DRα C-terminus (orange) and the DR1 peptide-binding groove (DRα cyan, DR1β blue, peptide green). Hydrogen bonds are displayed as dotted lines. (C) Similar view as (B), but overlaid with DR1 containing full-length HA peptide (gray). The DRα C-terminus occupies an overlapping space as P-2 and P-1 of the full-length peptide.