Figure 2. Effects of monoamine uptake inhibitors in the assay of acid-stimulated writhing.
Abscissae: Dose in mg/kg. Ordinates: Percent control writhes. All points show mean data±SEM from 5–6 rats, and ED50 values are reported in Table 1. The mean ± SEM number of control writhes for each group were as follows: citalopram 24.7±6.8; clomipramine 17.3±3.6; nisoxetine 21.9±0.5; nortriptyline 21.4±3.5; RTI-113 22.6±4.5; bupropion 16.3±2.3; milnacipran 17.9±2.3; RTI-112 19.5±3.8.
