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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Pain. 2013 Jan 16;14(3):246–259. doi: 10.1016/j.jpain.2012.11.006

Figure 5. Effects of the SNRIs nisoxetine (NIS, panels A-C, N=6) and nortriptyline (NORT, panels D-F, N=6) on control and acid-depressed ICSS.

Figure 5

Details as in Figure 4. Statistical results for two-way ANOVA of full frequency-rate curves are as follows: (A) Significant main effect of frequency [F(9,45)=21.3, p<0.001] and dose [F(3,15)=10.18, p<0.001]; the interaction was not significant [F(27,135)=0.68, p=0.875]. (B) Significant main effects of frequency [F(9,45)=26.94, p<0.001] but not dose [F(3,15)=2.25, p=0.124]; the interaction was significant [F(27,135)=2.07, p=0.003. (D) Significant main effect of frequency [F(9,45)=51.82, p<0.001] and dose [F(3,15)=9.58, p<0.001]; the interaction was significant [F(27,135)=3.27, p<0.001]. (E) Significant main effect of frequency [F(9,45)=87.57,p<0.001] and dose [F(3,15)=5.79, p=0.008]; the interaction was significant [F(27,135)=4.48, p<0.001].