Table 1.
ED50 values in mg/kg (95% confidence limits) for monoamine reuptake inhibitors to produce antinociception in the assays of acid-stimulated writhing or acid-induced depression of ICSS. “Inactive” indicates that a failure to produce at least 50% acid blockade in the assay of acid-depressed ICSS.
| Acid-Stimulated Writhing |
Acid-Depressed ICSS |
|
|---|---|---|
| Citalopram | 15.00 (10.74–23.50) | Inactive |
| Clomipramine | 7.77 (5.90–9.89) | Inactive |
| Nisoxetine | 0.62 (0.21–1.10) | Inactive |
| Nortriptyline | 2.55 (1.41–5.58) | Inactive |
| RTI-113 | 0.95 (0.39–2.12) | 0.20 (0.08–0.53) |
| Bupropion | 7.56 (5.04–10.52) | 1.75 (0.59–5.23) |
| Milnacipran | 1.14 (0.38–3.42) | Inactive |
| RTI-112 | 0.34 (0.09–1.28) | 0.12 (0.03–0.21) |