Table 2.

Significant differences in cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time-to-peak (TTP) at interictal stage between high (HF, >2 attacks, n=12) and low (LF, ≤2 attacks per month, n=13) frequency migraine and controls (n=16)

	Brain area	MNI coordinates (x y z)	Cluster - size	Z- value
CBF (ml/100g/min)
Increased
HF (64.9 [8.9]) vs. controls (50.8 [7.2])	L Medial frontal gyrus	‒6 26 38	88	4.71
HF (56.5 [4.8]) vs. LF (47.4 [4.9])	L Postcentral gyrus	‒38 −26 48	54	4.39
HF (67.0 [9.2]) vs. LF (56.5 [6.3])	L Precentral gyrus	‒58 0 6	27	4.05
HF (82.0 [8.5]) vs. LF (64.7 [9.4])	L Medial frontal gyrus	‒4 28 32	52	4.04
HF (72.0 [10.0]) vs. LF (59.3 [6.9])	R Putamen	38 −8 −2	65	3.92
HF (65.9 [7.0]) vs. LF (54.9 [7.9]	L Postcentral gyrus	‒62 −10 20	23	3.83
HF (48.3 [5.3]) vs. LF (38.2 [6.6])	L Medial frontal gyrus	‒32 18 44	30	3.82
HF (45.2 [6.9]) vs. LF (36.4 [4.4])	R Inferior parietal lobule	44 −28 24	103	3.81
HF (87.5 [14.4]) vs. LF (66.4 [8.3])	R Cingulate cortex	10 38 4	52	3.78
HF (67.6 [9.7]) vs. LF (57.3 [5.0])	R Superior frontal gyrus	8 −28 56	25	3.72
HF (58.1 [8.0]) vs. LF (46.6 [4.3])	R Middle frontal gyrus	32 46 26	43	3.58
HF (87.1 [10.0]) vs. LF (70.0 [11.0])	R Superior frontal gyrus	18 −62 16	30	3.52
HF (53.9 [12.5]) vs. LF (40.0 [6.9])	L Medial frontal gyrus	‒28 34 26	29	3.40
HF (58.5 [10.4]) vs. LF (50.0 [5.5])	R Inferior frontal gyrus	50 50 2	28	3.39
Decreased
LF (56.0 [6.5]) vs. controls (67.9 [13.3])	L Medial frontal gyrus	‒54 20 32	30	3.55
CBV (ml/100g), MTT (s), TTP (s)
No increases or decreases

MNI=Montreal Neurological Institute; p<0.001, uncorrected, cluster extent threshold of 20 voxels; between brackets mean [SD] CBF, CBV, MTT and TTP values of corresponding clusters across subjects per group