Fig. 3.

Cell autonomous developmental defects in IRF-2-deficient BM cells. (A) In BM chimeras reconstituted with control BM cells (control chimera) or with IRF-2-deficient BM cells (IRF-2 chimera), >99% of splenic CD11c^high cells gated as indicated were negative for Ly5.1. (B) CD4 vs. CD8α profiles for CD11c^high cells are shown. (C and D) The percentages of either CD4⁺ or CD8⁺ DCs within CD11c^high cells (C) or total spleen cells (D) were plotted for control and IRF-2 chimeras. Vertical bars represent the means of the data obtained with seven chimeras generated in three independent transfers.