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. 2013 Jul 7;288(32):22915–22929. doi: 10.1074/jbc.M113.484337

FIGURE 7.

FIGURE 7.

Evaluation of class I- and class IIa-selective DIs on post-ischemic regeneration. A, comparative analysis of tissue recovery after ischemia (14 days) in adductor muscles treated with the class IIa HDAC-specific inhibitor MC1568 or the class I-specific inhibitor MS275 (H&E-stained sections). B, comparative analysis of the same samples for the presence of fibrosis (Masson trichrome staining). *, p < 0.05 versus control. C, representative images showing desmin expression in ischemic muscles (14 days) treated with vehicle, MC1568, or MS275. D–F, evaluation of arteriogenesis (D and E) and capillarogenesis (F) in ischemic muscles at 3, 14, and 21 days from mice treated with vehicle, MC1568, or MS275. *, p < 0.05 versus control. Representative images of arterioles are shown for ischemic muscles treated with vehicle, MC, or MS at 14 days. G, measurements of limb perfusion by Lisca immediately after ischemia (T0) and at 2, 7, 14, and 21 days after ischemia. Error bars, S.E.