Table 2.
Pharmacokinetic and pharmacodynamic parameters for vancomycin between surviving and nonsurviving patients with methicillin-resistant Staphylococcus aureus pneumonia
| PK/PD parameters | Survivors (n = 62) | Nonsurvivors (n = 32) | P-value |
|---|---|---|---|
| Cmax (μg/mL) | 24.5 ± 8.2 | 25.5 ± 8.0 | 0.378 |
| Trough concentration (μg/mL) | 9.2 ± 8.2 | 10.0 ± 5.8 | 0.266 |
| AUC (μg*h/mL) | 344 ± 95.8 | 394.7 ± 209.9 | 0.104 |
| Vd (L) | 62.3 ± 6.6 | 63.6 ± 4.1 | 0.129 |
| T1/2 (hours) | 26.5 ± 13.1 | 31.5 ± 23.2 | 0.064 |
| CLr (mL/min) | 40.8 ± 16.9 | 35.5 ± 18.9 | 0.094 |
| Daily dose (mg/kg/day) | 20.9 ± 10.6 | 18.8 ± 6.6 | 0.119 |
| Dose interval (hours) | 26.5 ± 13.3 | 25.5 ± 7.8 | 0.322 |
Notes:P-values were determined by the Student’s t-test. Data were presented as the mean ± standard deviation.
Abbreviations: AUC, area under the curve; Vd, volume of distribution; CLr, renal clearance; PD, pharmacodynamic; PK, pharmacokinetic; Cmax, concentration max; T1/2, half-life.