Table 3.

Risk factors for mortality after treatment of methicillin-resistant Staphylococcus aureus pneumonia with vancomycin

Variable	Univariate analysis			Multivariate analysis
	Odds ratio	95% CI	P-value	Odds ratio	95% CI	P-value
Age	0.983	0.881–1.097	0.763
Nephrotoxicity	2.570	0.420–15.734	0.307	2.544	0.421–15.371	0.309
Infection severity	1.021	0.268–3.889	0.976
Charlson comorbidity index	1.236	0.924–1.654	0.154	1.236	0.941–1.625	0.128
Combination antibiotic therapy	0.745	0.195–2.852	0.667
Nonoptimal AUC (<250, >450 μg*h/mL)	25.377	5.791–111.203	< 0.001	23.156	6.814–78.687	< 0.001

Note: Hosmer–Lemeshow test, P = 0.134.

Abbreviations: AUC, area under the concentration curve; CI, confidence interval.