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. Author manuscript; available in PMC: 2013 Aug 14.
Published in final edited form as: Biochem J. 2011 May 15;436(1):91–100. doi: 10.1042/BJ20101891

Figure 2. Improved hepatic insulin signalling in PON2-def/apoE−/− mice.

Figure 2

(A) Mice (n = 3) were starved overnight and then administered human insulin at 5 units/kg of body weight intravenously. Liver was collected and insulin signalling assessed by detection of phosphorylation of IRS-1 at Tyr895 and Ser307. Values are means ± S.E.M. (B) GTT (left-hand panel) and ITT (right-hand panel) assessment of mice (n = 8–10) fed on a standard chow diet for 15 weeks. (C) GTT (left-hand panel) and ITT (right-hand panel) assessment of mice (n = 8–10) fed on a Western diet for 15 weeks. ○, control; ●, PON2-def. Values are means ± S.D. *P < 0.05.