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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Clin Epidemiol. 2013 Aug;66(8 0):S130–S137. doi: 10.1016/j.jclinepi.2013.02.015

Table 3.

Average sample size based upon 1,000 simulations per response rate scenario (Total) and average patients per treatment arm. Average randomization rates are shown in parentheses. Bold/italics indicate the most effective treatment arm(s).

Scenario Response Rates Total fPHT LEV VPA
Null
0.50 – 0.50 – 0.50		 507 169
(33%)		 169
(33%)		 168
(33%)
One Good
0.50 – 0.50 – 0.65		 483 126
(26%)		 127
(26%)		 230
(48%)
Two Good
0.50 – 0.65 – 0.65		 679 115
(17%)		 282
(42%) 		282
(42%)
One Middle One Good
0.50 – 0.575 – 0.65		 586 122
(21%)		 189
(32%)		 275
(47%)
All Bad
0.25 – 0.25 – 0.25		 524 173
(33%)		 172
(33%)		 179
(34%)
All Really Bad
0.10 – 0.10 – 0.10		 400 133
(33%)		 133
(33%)		 134
(33%)