Figure 8.

Changes of tumor mass after administration of cisplatin or cisplatin-incorporated (poly[acrylic acid-co-methyl methacrylate]-2-3) nanoparticles (NPs). CT26 cells were implanted into the backs of mice, and drug was injected after 2 weeks of tumor-cell implantation. The time for first drug injection was determined as day 0. Drug injection was done twice at an interval of 4 days. Phosphate-buffered saline was injected into control mice. cisplatin or NPs (dose: 5 mg/kg) were administered via the tail vein. The vehicle was administered with poly(acrylic acid-co-methyl methacrylate)-2 (50 mg/kg) into the mice. Five mice were used for each group.

Note: *,**P < 0.001.