Table 1.
Operational properties of the presented microfluidic device compared to the conventional module (Tracerlab FX-N™ from GE) and the commercial preclinical microfluidic system (Nanotek™ from Advion)
| This report | Tracerlab FX-N™ conventional module33,18 | Nanotek™ flow-through microfluidic | |
|---|---|---|---|
| Reactor volume | 50 μL | 5 mL | 31.4 μL34 |
| Max pressure in the reactor | 2 MPa | 0.4 MPa | 20 MPa |
| Radioactivity concentrationa | ~20 GBq mL−1 | ~1 GBq mL−1 | ~1 GBq mL−1b,35 |
| Volume of the mixture before purification | 0.7–1 mL | 4 mL | Process-specific |
| Sequential reactions in the reactor | Yes | Yes | No35 |
| Integration with purification | Yes | Yes | No35 |
| Number of production runs per day | 3 (limited by the process time) | 1 (instrument can not be reloaded) | 1 (instrument can not be reloaded) |
| Fluoride drying time | 240–300 s | 300–600 s | 1200 s36 |
a
Assuming 1 GBq of radioactivity delivered from the cyclotron.
b
Assuming a 1 : 1 fluoride : precursor ratio.