TABLE 3.
The number of metabolites that were significantly different between PAPOLG genotypes 1 and 2 before and after the intervention in volunteers within the high-glucoraphanin broccoli arm (n = 19)1
| Before intervention |
After intervention |
|||
| Pathway2 | Higher in genotype 1 | Higher in genotype 2 | Higher in genotype 1 | Higher in genotype 2 |
| Amino acids (85) | 8 | 3 | 1 | 5 |
| Carbohydrates (23) | 1 | 0 | 0 | 0 |
| Cofactors and vitamins (15) | 4 | 0 | 1 | 1 |
| Energy (9) | 3 | 0 | 0 | 0 |
| Acylcarnitines (12) | 8 | 0 | 0 | 0 |
| Lipids (129) | 32 | 0 | 0 | 23 |
| Nucleotides (14) | 2 | 0 | 1 | 3 |
| Peptides (14) | 0 | 1 | 0 | 0 |
| Xenobiotics (46) | 4 | 0 | 1 | 1 |
| Total (347) | 66 | 37 | ||
| Median number after Y scrambling3 | 15 | 15 | ||
| 4 | <0.0001 | <0.02 | ||
All values are the number of metabolites within each class that reached the achieved statistical threshold (P < 0.05). Details of the metabolites and P values are provided elsewhere (see Supplemental Table S5 under “Supplemental data” in the online issue). t Tests were used to analyze differences in the log2 ion intensity of each metabolite between the genotypes before and after the intervention.
Numbers in parentheses are the total number of metabolites within each class.
The values were derived after 75,528 permutations of the data set.
The probability that the total number of metabolites found to be different would have occurred by chance, estimated from the frequency distribution of metabolites that reached the statistical threshold (P < 0.05) after 75,528 permutations of the data set.