Table 1. Study design to investigate CWD vertical/maternal transmission.

Offspring cohort	Dam’s CWD status	Dam #	Offspring #	Dam’s clinical disease stage (cohort)	Offspring gestational stage
Full term viable	Positive	11*	242	Late (2)	Full term
		45	531	Late (2)	Full term
		46	551	Early (1)	Full term
	Negative	16	201	NCD (3)	Full term
		16	222	NCD (3)	Full term
		19	211	NCD (3)	Full term
		19	262	NCD (3)	Full term
Full term nonviable	Positive	11*	231	Early (1)	Full term
		50	541	Early (1)	Full term
		15	251	Late (2)	Full term
		47	511	Late (2)	Full term
		44	521	Late (2)	Full term died 10 dpb
		43	561	Late (2)	Full term died 2 dpb
	Negative	16	273	NCD (3)	Full term died 5 dpb
In utero harvest	Positive	47	572	Late (2)	Late gestation
		45	582	Late (2)	Late gestation
		50	592	Late (2)	Early gestation
	Negative	64	801	NCD (3)	Early gestation

^*Dam inoculated orally (PO) only. All other dams inoculated PO and subcutaneously (SC).

Late = > ½ time to dam terminal TSE disease.

Early = < ½ time to dam terminal TSE disease.

Late gestation = >3.5 months gestation.

Early gestation = <3.5 months gestation.

NCD = No clinical disease.

dpb = days post birth.

¹Dam’s first conception.

²Dam’s second conception.

³Dam’s third conception.