Table 2. IHC and PMCA CWD detection in offspring born to mock and CWD-infected muntjac.
Offspring cohort | Dam’s CWD status | Dam # | Offspring #/status | Offspring IHC | Offspring PMCA |
Full term viable | Positive | 11 | 24/cl, fair 58 mpb | 40*/102∧dpb | 376∧dpb |
45 | 53/cl, term 45 mpb | 504*∧dpb | 107*/301∧dpb | ||
46 | 55/cl, term 40 mpb | 465*/386∧dpb | 386*∧dpb | ||
Negative | 16 | 20 | Negative | Negative | |
16 | 22 | ND | Negative | ||
19 | 21 | ND | Negative | ||
19 | 26 | Negative | Negative | ||
Full term nonviable | Positive | 11 | 23 | ND | Pla, RLN, Sp, Ton, Pop, Mam |
50 | 54 | ND | Ob, Mes | ||
15 | 25 | ND | Ob, Pop | ||
47 | 51 | ND | Ob, Pla, Mes, Iln, Pop | ||
44 | 52/died 10 dpb | ND | Mes, Sp, RAMALT | ||
43 | 56/died 2 dpb | ND | RLN, Mes | ||
Negative | 16 | 27/died 5 dpb | ND | Negative | |
In utero harvest | Positive | 47 | 57 | ND | Ob, Pla, RAMALT |
45 | 58 | ND | Pla, Mes, Iln, I, RAMALT, Par | ||
50 | 59 | ND | Pla | ||
Negative | 64 | 80 | ND | Negative |
cl = clinical; fair = health condition; * = tonsil biopsy; ∧ = RAMALT biopsy; term = terminated due to clinical TSE disease; ND = not done; Pla = placenta; RLN = retropharyngeal lymph node; Sp = spleen; Ton = tonsil; Pop = popliteal lymph node; Mam = mammary lymph node; Ob = obex; Mes = mesenteric lymph node; Iln = Ileocecocolic lymph node; RAMALT = recto-anal mucosa associated lymphoid tissue; I = ileum; Par = parotid lymph node.