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. 2013 Aug 14;8(8):e71323. doi: 10.1371/journal.pone.0071323

Figure 3. Effect of Cpd-60 treatment on mood-related behaviors in mice.

Figure 3

(a) Timecourse of locomotor activity in response to and (b) total locomotor activity summed over 80 min following acute amphetamine challenge (3.5 mg/kg, i.p.; Time ‘0’ indicated by arrow). Hyperlocomotion in response to amphetamine was significantly reduced in mice chronically treated with Cpd-60 (45 mg/kg, i.p.) but not with SAHA (25 mg/kg, i.p.). (c) Time spent immobile in the forced swim test was significantly decreased in mice treated chronically with Cpd-60 but not SAHA compared to vehicle treated control mice. *p<0.05, **p<0.01, ANOVA with Least Significant Difference post hoc test.