Table 3. Enriched genes in the 30 top Gene Ontology (GO) terms.
Genea | # terms involved | Ratio of significant SNPsb | Most significant SNP | p-valuec |
PARK2 | 6 | 28/512 | rs574165 | 0.001 |
UBR3 | 6 | 2/36 | rs16857407 | 0.020 |
ANAPC10 | 5 | 1/8 | rs1455137 | 0.035 |
BRAP | 5 | 1/11 | rs10744774 | 0.019 |
CADM1 | 5 | 2/72 | rs6589485 | 0.006 |
CARD8 | 5 | 5/23 | rs10416565 | 0.008 |
CBL | 5 | 2/13 | rs2249466 | 0.027 |
CRTAM | 5 | 2/22 | rs3107606 | 0.009 |
DDB2 | 5 | 2/7 | rs3781619 | 0.013 |
FBXL6 | 5 | 3/8 | rs3817681 | 0.016 |
FBXO22 | 5 | 3/5 | rs335675 | 0.011 |
FBXO3 | 5 | 1/28 | rs831627 | 0.004 |
FBXO7 | 5 | 8/29 | rs738263 | 0.007 |
GLMN | 5 | 1/3 | rs3103174 | 0.017 |
INS | 5 | 3/9 | rs11042978 | 0.002 |
MALT1 | 5 | 3/22 | rs9783885 | 0.021 |
MYLIP | 5 | 6/18 | rs11969250 | 0.004 |
NLRP3 | 5 | 3/40 | rs9988572 | 0.001 |
RNF217 | 5 | 2/42 | rs552705 | 0.029 |
SMURF1 | 5 | 2/16 | rs12672417 | 0.020 |
UBE2D2 | 5 | 2/7 | rs769052 | 0.033 |
UBE2E1 | 5 | 4/20 | rs12629302 | 0.008 |
UBE2H | 5 | 1/24 | rs10246707 | 0.024 |
UBE2L3 | 5 | 1/10 | rs13054355 | 0.006 |
UBE2M | 5 | 3/8 | rs7249714 | 0.006 |
UBR5 | 5 | 4/27 | rs10102559 | 0.003 |
UHRF2 | 5 | 1/24 | rs1547258 | 0.030 |
WWP2 | 5 | 3/28 | rs7200005 | 0.011 |
ZER1 | 5 | 1/4 | rs10988111 | 0.017 |
APOA1 | 4 | 1/6 | rs10047459 | 0.015 |
CCKBR | 4 | 2/19 | rs2880829 | 0.004 |
CIDEA | 4 | 1/16 | rs8084404 | 0.040 |
FOXP3 | 4 | 1/7 | rs5906761 | 0.016 |
NLRP12 | 4 | 2/19 | rs7259148 | 0.005 |
ROBO2 | 4 | 15/171 | rs9836971 | 0.005 |
SLIT2 | 4 | 6/106 | rs12503652 | 0.003 |
Genes that have at least one SNP with a p-value < 0.05 and are involved in at least 4 gene sets were listed.
The numerator is the number of SNPs with a p-value < 0.05 in a gene and the denominator is the total number of SNPs mapped to the gene.
The p-value of the most significant SNP in the gene.