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. 2013 Aug 14;8(8):e71480. doi: 10.1371/journal.pone.0071480

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© 2013 Saito et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The significance of miR-196a as a promising biomarker for laryngeal cancer was confirmed by TaqMan® qRT-PCR using 84 tissue samples. The assay also included 7 HNSCC cell lines. Noncancerous counterparts (NCs) are shown as open quadrangles. Bars indicate mean value of each group. (B) Expression level of miR-196a was higher in advanced (T3 and T4) cancers compared with early cancers (T1 and T2) (left panel). Furthermore, significantly higher level of miR-196a expression was observed in early T1a cancer samples compared with precancerous dysplasia samples (right panel). Bars indicate mean value of each group. *, p<0.05.