Table 5. Bone marrow adipocyte genes most highly up- and down-regulated by a high fat diet at 6 months of age.
| Symbol | Entrez Gene Name | Fold change | P value |
|---|---|---|---|
| KLF2 | Krüppel-like factor 2 (lung) | 5.9 | 9.56E-06 |
| RHOB | ras homolog gene family, member B | 4.9 | 5.15E-07 |
| KLF4 | Krüppel-like factor 4 (gut) | 4.2 | 7.30E-05 |
| PLK2 | polo-like kinase 2 (Drosophila) | 3.7 | 1.48E-07 |
| SH2D1B | SH2 domain containing 1B | 3.5 | 1.32E-08 |
| ENO3 | enolase 3 (beta, muscle) | 3.5 | 2.88E-05 |
| ADRB2 | adrenergic, beta-2-, receptor, surface | 3.1 | 1.46E-07 |
| NLRP3 | NLR family, pyrin domain containing 3 | 3.0 | 0.000121 |
| DUSP2 | dual specificity phosphatase 2 | 2.8 | 0.000697 |
| EGR1 | early growth response 1 | 2.8 | 0.004784 |
| MT1E | metallothionein 1E | -2.7 | 0.000561 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -2.7 | 2.98E-05 |
| ITGA6 | integrin, alpha 6 | -2.8 | 0.000123 |
| PLS1 | plastin 1 | -2.9 | 7.20E-05 |
| PRKCA | protein kinase C, alpha | -3.1 | 1.66E-08 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | -3.8 | 1.07E-05 |
| ITGA2B | integrin, alpha 2b | -3.8 | 2.94E-05 |
| CYSLTR2 | cysteinyl leukotriene receptor 2 | -4.2 | 5.89E-05 |
| IL6 | interleukin 6 (interferon, beta 2) | -4.9 | 1.60E-06 |
| F2RL2 | coagulation factor II receptor-like 2 | -8.2 | 5.89E-07 |
The list includes the adipocyte genes that change with high fat diet feeding at 6 months of age in bone marrow adipocytes. The set of regulated genes was selected on the basis of their expression in adipose cells according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes in standard chow and high fat fed with fold change ± 2 and p <0.05. The 6-month-old fed with high fat diet were compared to 6-month-old fed with standard chow diet. The significance of differences was measured by two-way ANOVA.