Table 2.
Breeding analysis of mice containing the 2275 inversion
| Parent | Number of mice
|
||||
|---|---|---|---|---|---|
| Progeny | Transgenic | Parental transgene | Transgene deletion | Homologous recombinants (expansion mice) | |
| 2275 | 36 | 16 | 7 | 6 | 3* |
| 2949 | 40 | 21 | 14 | 6 | 1* |
| 3308 | 16 | 9 | 1 | 3 | 5 (mice 3645, 3679, 3692) |
| 3368 | 25 | 8 | 2 | 3 | 3 (mice 3688, 3691) |
| Total: | 117 | 54 (46%) | 24 | 18 | 12 |
Data for mice 2275 and 2949 have been previously reported (9).
The transgene structures in these mice were not examined in as much detail as in subsequent mice, but more limited analysis suggested that each had undergone a transgene expansion.