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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Biochem J. 2013 Sep 1;454(2):191–200. doi: 10.1042/BJ20130317

Figure 5. Structure-activity-relationship study of pyrazolopyrimidine inhibitors of APH(3’)-Ia.

Figure 5

A) Chemical structures of parent compounds and derivatives grouped by modification site. B) Measured inhibitory constants (Ki) of compounds against APH(3’)-Ia. C) Chemical synthesis scheme for compounds NT6-66 and NT6-67. Method adapted from Todorovic, N., Awuah, E., Shakya, T. & Wright, G. Microwave-assisted synthesis of N1-and C3-substituted pyrazolo [3, 4-d] pyrimidine libraries. Tetrahedron Letters (2011).