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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Pharm Sci. 2013 May 13;102(9):3070–3081. doi: 10.1002/jps.23550

Fig. 1.

Fig. 1

The Thionitrate Oxidation Hypothesis of organic nitrate metabolism, bioactivation, and enzyme inactivation. PS = cysteine-containing proteins; SG = glutathione residue,-SO2H = sulfinic acid protein modification and -SO3H = sulfonic acid modification. Adapted from Fung71