. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: J Pharm Sci. 2013 May 13;102(9):3070–3081. doi: 10.1002/jps.23550

Table 1.

Summary of enzymes known to metabolize organic nitrates

Class	Isoforms	ORN Metabolized	ORN NOT Metabolized	Predominant NTG metabolite	References
GST	GSTmu	NTG, ISDN	nicorandil	1,2-GDN	^24,45
GST	MGST1	NTG		1,3-GDN	^24,47
Xanthine Oxidase		NTG, ISDN, IS-5-MN, IS-2-MN		1,2-GDN	^34,50,51
Cytochrome P450	3A4	NTG, ISDN, NO-aspirin		N.D.	^{54–56,59,60}
	2B11	NTG		N.D.	^54–56
	2J2, 1A2, 2A6, 2C9, 2E1	ISDN, NO- aspirin		N.D.	^59,60
Aldehyde Dehydrogenase	ALDH1a1	NTG, ISDN, IS-5-MN, IS-2-MN, nicorandil		1,2-GDN	^42,43
	ALDH2	PETN, NTG, ISDN, nicorandil	IS-2-MN, IS-5-MN	1,2-GDN	^35,64,42,138
	ALDH3a1	NTG, ISDN, IS-2-MN, nicorandil	IS-5-MN	1,2-GDN	⁶⁹

(N.D. = no available data)