Table 1.
[ch128.1Av] nM | [HXR9] µM | Fa | CI | Description |
---|---|---|---|---|
2.5 | 20 | 0.987 | 0.503 | Synergism |
5 | 20 | 0.997 | 0.382 | Synergism |
10 | 20 | 0.980 | 0.551 | Synergism |
20 | 20 | 0.986 | 0.515 | Synergism |
30 | 20 | 0.983 | 0.541 | Synergism |
2.5 | 10 | 0.781 | 0.862 | Moderate Synergism |
5 | 10 | 0.852 | 0.705 | Moderate Synergism |
10 | 10 | 0.899 | 0.609 | Synergism |
20 | 10 | 0.906 | 0.764 | Moderate Synergism |
30 | 10 | 0.928 | 0.667 | Synergism |
Analysis was performed using the Calcusyn software (BioSoft). Fa = fraction affected as tested by the [3H]-thymidine incorporation assay, CI = combination index. Descriptions are based on CI values and the recommendations of BioSoft: < 0.1 = very strong synergism, 0.1–0.3 = strong synergism, 0.3–0.7 = synergism, 0.7–0.85 – moderate synergism, 0.85–0.9 = slight synergism.