Figure 1.

Mapping between underlying developmental causes of connectome changes, ranging from genetic factors to spatiotemporal epigenetic factors, to resulting brain connectivity (“connectome”), observable network behavior (“consequence”), and final disease classification. Similar patterns within each of the four categories are shown in red. Note that both genetic patterns and network features alone may be insufficient to inform the clinical diagnosis of a disease: first, the same genetic mutation A might lead to a different connectivity due to different epigenetic factors. Second, different genetic mutations A and B could lead to the same connectivity due to additional factors. Third, the same connectivity might lead to different behavior and disease classification due to changes that solely affect the anatomical organization within individual nodes.