Skip to main content
. Author manuscript; available in PMC: 2013 Oct 15.
Published in final edited form as: Life Sci. 2012 Feb 16;91(0):676–680. doi: 10.1016/j.lfs.2012.01.020

Fig. 2.

Fig. 2

Effects of acute endothelin receptor antagonism on endothelium-dependent relaxation in stroked rats (S). in stroked rats. A) Dose response curves to Ach in ET-1-preconstricted vessels demonstrated impaired relaxation in antagonism with atrasentan (A) partially restored it. B) stroked rats (S) and ETA The magnitude of dilation was less in stroked rats and atrasentan treatment improved relaxation. C) There was a trend for improved sensitivity (EC50) to acetylcholine with ET receptor antagonism. (*p<0.05 vs control, +p<0.05 and **p<0.01 vs stroked rats).