Fig. 4.

INT-767 stimulates ${\text{HCO}}_3^{-}$-rich bile flow in Mdr2^−/− mice. Bile flow and composition were measured in Mdr2^−/− mice after 7 days of feeding either a chow or a diet supplemented with INT-747, INT-777, or INT-767. (A) INT-767 increased bile flow and (B) biliary ${\text{HCO}}_3^{-}$ output. (C) Biliary BA output was significantly decreased by INT-767. Neither INT-747 nor INT-777 modified bile flow, biliary ${\text{HCO}}_3^{-}$, or BA output in Mdr2^−/− mice. Means of 4–5 mice/ group ± SD are presented. *P < 0.05 INT-767 versus chow-fed Mdr2^−/− mice (Co).