Table 4. Odds ratio estimates* for SNPs located in coding regions of genes (the Northern California Childhood Leukemia Study, 1996-2002).
| GENE | SNPs | Overall | Hispanics | Non-Hispanics | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| Numbers |
OR (95% CI) | Numbers |
OR (95% CI) | Numbers |
OR (95% CI) | |||||
| Ca | Co | Ca | Co | Ca | Co | |||||
| MTHFD1 | rs1950902 (K134R) | |||||||||
| R/R | 263 | 302 | 1.00 | 112 | 140 | 1.00 | 151 | 162 | 1.00 | |
| R/K | 98 | 124 | 0.92 (0.67-1.26) | 40 | 31 | 1.62 (0.95-2.75) | 58 | 93 | 0.67 (0.45-1.00) | |
| K/K | 12 | 17 | 0.82 (0.38-1.77) | 1 | 5 | 0.25 (0.03-2.17) | 11 | 12 | 0.99 (0.42-2.32) | |
| MTHFR | rs1801131 (E429A) | |||||||||
| E/E | 190 | 238 | 1.00 | 86 | 110 | 1.00 | 104 | 129 | 1.00 | |
| E/A | 159 | 184 | 1.10 (0.82-1.47) | 60 | 62 | 1.24 (0.79-1.95) | 99 | 121 | 1.02 (0.70-1.49) | |
| A/A | 26 | 24 | 1.37 (0.76-2.48) | 8 | 6 | 1.72 (0.57-5.19) | 18 | 18 | 1.24 (0.61-2.51) | |
| rs1801133 (A222V) | ||||||||||
| A/A | 169 | 186 | 1.00 | 62 | 59 | 1.00 | 107 | 127 | 1.00 | |
| A/V | 159 | 214 | 0.80 (0.60-1.08) | 72 | 91 | 0.74 (0.46-1.20) | 87 | 123 | 0.84 (0.57-1.24) | |
| V/V | 47 | 46 | 1.10 (0.69-1.75) | 20 | 27 | 0.69 (0.35-1.38) | 27 | 19 | 1.72 (0.89-3.31) | |
| MTR | rs1805087 (D919G) | |||||||||
| G/G | 237 | 292 | 1.00 | 99 | 11 | 1.00 | 138 | 181 | 1.00 | |
| G/D | 123 | 137 | 1.11 (0.82-1.49) | 51 | 60 | 0.97 (0.61-1.55) | 72 | 77 | 1.22 (0.83-1.81) | |
| D/D | 16 | 18 | 1.11 (0.55-2.22) | 5 | 7 | 0.78 (0.24-2.56) | 11 | 10 | 1.46 (0.60-3.56) | |
| MTRR | rs2966952 (R56K) | |||||||||
| R/R | 253 | 301 | 1.00 | 109 | 132 | 1.00 | 144 | 169 | 1.00 | |
| R/K | 114 | 127 | 1.08 (0.80-1.47) | 46 | 41 | 1.36 (0.83-2.23) | 68 | 86 | 0.93 (0.63-1.38) | |
| K/K | 9 | 16 | 0.69 (0.30-1.60) | 1 | 4 | 0.29 (0.03-2.72) | 8 | 12 | 0.79 (0.31-2.00) | |
| rs1801394 (I49M) | ||||||||||
| I/I | 133 | 145 | 1.00 | 74 | 84 | 1.00 | 59 | 61 | 1.00 | |
| I/M | 178 | 220 | 0.88 (0.64-1.21) | 69 | 74 | 1.05 (0.67-1.66) | 109 | 146 | 0.77 (0.49-1.20) | |
| M/M | 66 | 82 | 0.88 (0.58-1.35) | 13 | 21 | 0.69 (0.32-1.49) | 53 | 61 | 0.90 (0.53-1.53) | |
| rs2287779 (L412L) | ||||||||||
| G/G | 310 | 389 | 1.00 | 108 | 145 | 1.00 | 202 | 244 | 1.00 | |
| G/A | 64 | 57 | 1.43 (0.96-2.13) | 46 | 33 | 1.92 (1.14-3.25) | 18 | 24 | 0.91 (0.48-1.74) | |
| A/A | 3 | 2 | 1.92 (0.32-11.7) | 2 | 1 | 2.69 (0.24-30.2) | 1 | 1 | 1.18 (0.07-19.8) | |
| rs10380 (H622Y) | ||||||||||
| H/H | 252 | 293 | 1.00 | 82 | 79 | 1.00 | 170 | 213 | 1.00 | |
| H/Y | 103 | 131 | 0.88 (0.63-1.22) | 59 | 78 | 0.73 (0.46-1.15) | 44 | 54 | 1.00 (0.63-1.58) | |
| Y/Y | 20 | 23 | 0.97 (0.51-1.84) | 13 | 22 | 0.57 (0.27-1.22) | 7 | 1 | 8.69 (1.06-71.6) | |
| rs1802059 (A664A) | ||||||||||
| G/G | 189 | 238 | 1.00 | 98 | 117 | 1.00 | 91 | 121 | 1.00 | |
| G/C | 161 | 167 | 1.23 (0.91-1.65) | 53 | 48 | 1.33 (0.82-2.15) | 108 | 119 | 1.20 (0.82-1.76) | |
| C/C | 26 | 43 | 0.77 (0.45-1.30) | 4 | 14 | 0.34 (0.11-1.07) | 22 | 29 | 1.00 (0.54-1.88) | |
| SLC19A1 | rs1051266 (H27R) | |||||||||
| R/R | 106 | 132 | 1.00 | 49 | 49 | 1.00 | 58 | 83 | 1.00 | |
| R/H | 188 | 205 | 1.12 (0.81-1.56) | 74 | 89 | 0.83 (0.50-1.37) | 115 | 122 | 1.34 (0.87-2.05) | |
| H/H | 54 | 85 | 0.76 (0.49-1.18) | 21 | 35 | 0.59 (0.30-1.17) | 34 | 51 | 0.94 (0.53-1.65) | |
*
Adjustment for Hispanic ethnicity (when all subjects were analyzed together), age, sex, race.