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Improvements in cumulative relative survival were observed in successive TT trials, whether considered from onset of therapy (a) or from onset of CR (b). OS was adjusted for the expected survival of the US population, stratified by gender and age at registration. Successive improvements were noted when comparing TT1 with TT2 and with TT3. No difference was detected between TT2 − Thal and TT2 + Thal. Black, TT1; blue, TT2 − Thal; red, TT2 + Thal; and green, TT3.
