Figure 4.

Nonlinearity in the synergism: the example of Guanylate kinase. The part of the human network here represented shows the nonlinear interaction when the three drug targets (the three valves, with the name of the drugs) are simultaneously inhibited: when this is the case, the objective reaction of Guanylate kinase (in red) is stopped. Gray arrows and gray circles indicate respectively stopped reactions and metabolites which become unavailable.