. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Inflamm Bowel Dis. 2013 Jan;19(1):115–123. doi: 10.1002/ibd.22974

Table 2. IL-10R Polymorphisms Associated with VEO-IBD.

Odds ratios using DD vs. Dd/dd model. Discovery Cohort: VEO-IBD (n=65), VEO-UC (n=41), VEO-CD (n=24), and controls (n=188). Validation Cohort: VEO-IBD (n=28), VEO-UC (n=18), VEO-CD (n=10), and controls (n=480). Threshold for significance in Validation cohort was 0.007 to correct for multiple testing.

		Discovery Cohort		Validation Cohort		Combined Cohorts

IL10RA SNP		OR	p value	OR	p value	OR	p value
rs10892202	VEO-IBD	0.41	0.044	1.17	0.701	0.60	0.086
	VEO-UC	0.28	0.030	0.71	0.585	0.40	0.032
	VEO-CD	0.62	0.230	2.35	0.179	0.98	0.951
rs2228054	VEO-IBD	2.69	0.016	2.58	0.024	2.49	3×10⁻³
	VEO-UC	3.29	0.013	3.86	0.005	3.08	2×10⁻⁴
	VEO-CD	1.85	0.140	1.93	0.404	1.66	0.273
rs2228055	VEO-IBD	2.38	0.032	2.80	0.014	2.56	2×10⁻³
	VEO-UC	2.58	0.058	4.21	0.003	2.93	6×10⁻⁴
	VEO-CD	2.08	0.057	2.10	0.345	2.01	0.106
rs4252249	VEO-IBD	0.41	0.045	1.18	0.701	0.61	0.882
	VEO-UC	0.28	0.046	0.71	0.585	0.40	0.033
	VEO-CD	0.63	0.240	2.35	0.179	0.98	0.958
rs4252270	VEO-IBD	0.41	0.045	1.16	0.722	0.60	0.081
	VEO-UC	0.28	0.046	0.70	0.572	0.40	0.031
	VEO-CD	0.62	0.240	2.32	0.186	0.97	0.938

IL10RB SNP		OR	p value	OR	p value	OR	p value

rs1058867	VEO-IBD	1.55	0.186	0.94	0.868	1.16	0.515
	VEO-UC	1.28	0.596	1.13	0.814	1.10	0.748
	VEO-CD	2.11	0.058	0.56	0.364	1.26	0.519
rs8178561	VEO-IBD	0.70	0.528	1.23	0.687	0.92	0.804
	VEO-UC	1.04	1.000	1.89	0.267	1.32	0.447
	VEO-CD	0.23	0.212	0.74	0.260	0.37	0.160